This course examines U.S. healthcare delivery and population health using a systems-thinking approach within a dynamic policy, payment, regulatory, and operational environment. Students explore how care is organized, financed, and regulated across settings and how these factors influence access, cost, quality, patient experience, equity, and population health outcomes. The course considers how social determinants of health, prevention strategies, and emerging payment and delivery models interact with delivery system design to shape organizational performance and community health results. Emphasis is placed on interpreting current system and policy developments and translating insights into strategic decisions and population health action, with a focus on regional and rural contexts. Cross-listed with PH 430. Dual-listing: PH 630, HMA 630.