This course provides applied training in biostatistics and data-driven decision making for health systems professionals. Students analyze quantitative and qualitative health data using statistical software and apply descriptive and inferential methods, including an introduction to regression modeling, to inform research, policy, and organizational strategy. The course integrates population health analytics, key performance indicator (KPI) development, evaluation methods, implementation measurement, and innovation analytics within regional and rural health contexts. Emphasis is placed on interpreting results to improve cost, quality, equity, prevention outcomes, and population health. Students learn to distinguish research, quality improvement, and operational analytics and to translate findings into leadership-level recommendations. This course fulfills biostatistics competencies for public health students and analytic, evidence-based management competencies for healthcare administration students. Cross-listed with PH 755.